Tiki Casts a Spell on Wnt

Tiki Casts a Spell on Wnt

Negative feedback is a widespread feature of signaling pathways. In an unexpected twist described in this issue, He and colleagues identify a membrane-tethered metalloprotease named Tiki that inhibits Wnt signaling by removing an essential eight-residue fragment from Wnt itself.

When heat casts a spell on the DNA damage checkpoints

Peregrine Laziosi (1265-1345), an Italian priest, became the patron saint of cancer patients when the tumour in his left leg miraculously disappeared after he developed a fever. Elevated body temperature can cause tumours to regress and sensitizes cancer cells to agents that break DNA. Why hyperthermia blocks the repair of broken chromosomes by changing the way that the DNA damage checkpoint ki...

Harry Potter casts a spell on accident prone children.

Merlin casts its spell on the cortical cytoskeleton

On Tag Spell Checking

Exploiting the cumulative behavior of users is a common technique used to improve many popular online services. We build a tag spell checker using a graph-based model. In particular, we present a novel technique based on the graph of tags associated with objects made available by online sites such as Flickr and YouTube. We show the effectiveness of our approach on the basis of an experimentatio...